BRCA Basics

  • What are BRCA genes?
  • What is the connection between BRCA mutations and prostate cancer?
  • About prostate cancer

What are BRCA genes?

Cog, Wrench & DNA Strip

Every cell in our body contains DNA. This DNA is continually being damaged by various factors. Fortunately, our cells have DNA repair mechanisms that help address this damage as it happens. BRCA genes are present in everyone's cells. These genes help repair DNA damage.1

  1. Abida, W, et al, Targeting DNA repair in prostate cancer. Journal of Clinical Oncology. 2018; 1017-1019.

What is the connection between BRCA mutations and prostate cancer?

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Men who have a BRCA mutation are at a higher risk for developing prostate cancer than men without a BRCA mutation.2

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Men who are diagnosed with prostate cancer and also have a BRCA mutation are more likely to have an aggressive form of cancer.3

  1. Leongamornlert D, Mahmud N, Tymrakiewicz M, et al. Germline BRCA1 mutations increase prostate cancer risk. Br J Cancer. 2012;106(10):1697-1701.
  2. Castro E, Goh C, Olmos D, et al. Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer. J Clin Oncol. 2013;31(14):1748-1757.

About prostate cancer

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In the United States, prostate cancer is the second most common cancer among men, after skin cancer.4

  1. Prostate Cancer: Statistics

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